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Happy New Year! Welcome back to Ferrebeekeeper. We’ll talk about the perils and sweet promises of 2018 later this week. It is a year which offers much…assuming we can prevent complete political meltdown, war, and pestilential horror (and can manage our empty & overheating economy into something more useful). There is another election coming (thank goodness). Innovation,experimentation, and exploration, though woefully underfunded, still continue.Here at the old blogstead, I am adding some new topics and leaving behind some older themes which are played out. Also, for my professional life, I am planning a big new art project and some exciting shows. So keep watching for details on all of these things!
But first I want to start the year with a homily from my grandmother. Grandma Ferrebee is (locally) famous for her kindness and generosity, but also for her earthy wit and her grasp of the barnyard fundamentals which underlay the (thin) veneer of society. Additionally, she ran a beer hall in rural West Virginia for decades so beneath the affable exterior is the cold steel required to run a small business of any sort, much less one with a lot of drunken hillfolk running amok. I didn’t always appreciate her bucolic wisdom when I was younger (the scatological nature often struck me as unseemly) yet lately this fable seems uniquely apt. Here it is (paraphrased):
Once upon a time the organs of the body became embroiled in a noisy contest concerning which organ was preeminent and controlled the body.
The brain said “I am the seat of intellect and I direct all of the conscious and unconscious nervous impulses. The limbs do what I say and the body responds to my commands. I alone can apprehend the future and create lofty abstruse thoughts of things beyond rude physicality. I properly and truly rule the body.”
The heart then replied “I am the seat of emotions. Your fears and joys…your hatred and yearning comes from me. I am synonymous with love–eternal and sublime! Plus, on a more literal level, I pump the blood which make all of the organs function. The heart is the center of a person and I am the most important organ.”
Then, before any of the other organs could say their piece, the ass stopped working: the system filled up with shit and the whole body died.
It’s…uh..pithier when Grandma tells it with her West Virginia twang and her knowing looks, but I think I have conveyed the fundamental message. It is a message we need to think about in our “United” States. This red/blue rubbish is useful for pundits, but poisonous for a functioning nation. Our political parties of increasing furious ideological purity are becoming like some autoimmune illness. Ayn Rand Republicans who believe that a healthy and robust society can exist without a thriving middle class and contented workers (to say nothing of scientists, creative professionals, and technocrats) are deadly con-artists misleading us into disaster
Likewise democrats who split hairs over esoteric social manners, and carp forevermore on status conveyed by hereditary victimization left over from bygone eras have lost sight of the future as well. We have a motto about how things are supposed to work.
It is a dangerous time for our nation. I am writing here about The United States, which I know best, but all of the great democracies are afflicted by a wave of strife and malaise…indeed the whole world is convulsed by change so rapid that only authoritarian nations are dealing with it at all (mostly by pilfering the till and building Potemkin cities). We can talk about the larger ramifications of this in the coming year, but first we need to talk and listen instead of shouting slogans like we are in the cultural revolution or something. Democracy is not inferior to whatever China calls its brand of oppressive authoritarianism, but we need some reforms to make it work right. And we need to be patient and compassionate with each other while this process happens.
Above all, we must remember that, just like in the story, society needs people of all sorts in order to function. The nation needs both the sharp-eyed riflemen from Kentucky and the shrewd-minded accountants from Montclair. The states are deeply heterogeneous but stand beside each other through any crisis–structural, cyclical, or natural. We are not the “Fiscally Independent and Selfishly Aloof States of America”. Our name is much finer than that. We need the brain and the heart (and everything else) to work together if we are going to move forward…or even survive (for with a vastly greater population, our margins for error have shrunk). Also we need to go back and think symbolically when we look at this story and not just put the ass in control.
This week’s big science news is that researchers have finally sequenced the gene for a cephalopod– the California two-spot octopus, Octopus bimaculoides. Geneticists and molecular biologists from the University of Chicago and Berkley worked together to unravel the entire gene—which turned out to be nearly as large as the human genome and did not contain any mass data duplication (which some vertebrate-centric scientists had thought might account for the size and complexity). To quote Business Insider, “The work will allow scientists to study the genetic factors that give way to the octopus’ odd physical traits, and may reveal novel insights not only about the unique biology of cephalopods, but also about the evolution of traits that give rise to a complex nervous system and adaptive camouflage.”
There are already some fascinating initial discoveries from the octopus gene sequence data. Not surprisingly, the scientists discovered completely unique genomic sequences for reflectins (which allow the octopus to change color instantly). Even more intriguingly, the researchers discovered a huge suffusion of protocadherins—which facilitate the interaction between neurons. Octopus seem to have many more of these neural development genes than expected–and indeed the eight legged sea creatures have twice as many protocadherins as more familiar mammalian creatures like humans. However the majority of the data requires additional study. Scientists also hope to contextualize the somewhat abstract genes by sequencing other cephalopods (particularly cuttlefish—which a different team is working on).
Unfortunately I am not a geneticist and the niceties of jumping genes are somewhat lost on me. I am however greatly interested in finding out more about the biology and evolutionary history of cephalopods. This class of organisms has attained a shockingly high degree of intelligence through a very different evolutionary path than the most intelligent vertebrates (like primates, proboscideans, cetaceans, and parrots). The clever mollusks are capable of solving difficult puzzles in unexpected ways and their donut shaped brains have long perplexed and intrigued neurologists. Perhaps further details of their genetic makeup will yield the seed for tomorrow’s transgenically created superbrains! Barring that, it would be good to understand the mechanisms of diverse neural systems and grasp more about the development of these beautiful yet unfamiliar creatures.
In recent years, bioethicists and neurological surgeons have been troubled by accounts of a controversial surgery being widely performed in China. The procedure in question consists of surgically destroying the pleasure center of the brain in order to prevent opium addicts and alcoholics from relapsing into their addictions. As you might imagine, destroying the physiological structure responsible for one of the most fundamental human motivations does frequently solve addiction problems. Unfortunately, the surgery also tends to do away with longing, joy, and basic motivation to do anything. The Chinese authors of the papers put a more positive spin on these results and described the post-operative subjects as “mildness oriented” (i.e. compliant).
This surgical procedure is technically known as “ablation of the nucleus accumbens” and involves cutting open a subject’s skull and using heat to destroy small portions of the brain (which are recursively located in both hemispheres of the brain). Time Magazine (in this useful article) describes the two nucleus accumbens as regions of the brain “saturated with neurons containing dopamine and endogenous opioids, which are involved in pleasure and desire related both to drugs and to ordinary experiences like eating, love and sex.” This procedure is performed while subjects (one shies away from saying “patients”) are awake and conscious in order to minimize damage to other regions of the brain responsible for speech, memory, and movement.
The western medical/scientific community is trying to figure out how to approach this procedure. General consensus seems to be that the procedure is “horribly misguided” (apparently a medical euphemism for “a crime against humanity”), however a number of American and European doctors recommend publishing the results of these experimental surgeries in order to further understanding of the human brain–while not actually recommending the procedure. While the surgery does result in a recovery-rate from addition a few percentage points higher than counseling or other non-surgical therapies, it also frequently results in loss of memory, radical personality change, and other emotional problems (not to mention occasional serious problems such as death or coma which are an inherent danger of brain surgery).
A while ago I read a science fiction novel set in the far future. People who were anxious or miserable could volunteer for Radical Anxiety Termination—a procedure which fully eliminated depression, fear, and suffering, albeit at the cost of all personal volition. The Radical Anxiety Termination participants immediately became slaves who were sold and traded for whatever uses their masters desired. The novel was predictably troubling. It does not seem like the Chinese medical establishment has yet perfected Radical Anxiety Termination but they are on the dark road to such an outcome and they need to leave that twisted path immediately. Just as lobotomies performed in Europe and the United States during the early 20th century proved to be a therapeutic dead end (and a terrible, terrible mistake) so too this surgery is a collective degradation to emotionally ill victims and a fundamental attack on human dignity.
Have you ever watched a tiny red ant scurrying through the backyard only to be astounded that the ant seems like a giant when it walks by some much smaller black ants? Such observations have always caused me to wonder how small insects could become. What are the smallest insects out there and just how tiny are they? The answer is actually astonishing, and, like most good answers it just brings up more questions. Most entomologists believe the tiniest living insects are the fairyflies, infinitesimally minute parasitoid wasps which live on or inside the tiny eggs of thrips(well, some fairflies also live inside the brains of other insects, but let’s not think about that right now). Fairyflies are smaller than many single cell organisms like paramecia, amoebas, and euglenas. Dicopomorpha echmepterygis, a wasp from Costa Rica, is an astonishing .13 millimeters in length. Although many of these wasps fly, they are so tiny that they don’t have conventional wings: some of the smaller specimens have long cilia-like hairs which they use to row through the air (the fluid dynamics of which are considerably different for creatures so small).
In fact the wasps are so tiny that the millions of individual cells which make up their tissues and organs have to be very miniscule indeed. In fact, according to physics, the brains of fairyflies should not work. Many of the neural axons are smaller than 0.1 micrometre in diameter (and the smallest axons were a mere 0.045 μm). At such sizes, the electrical action of axons should not work properly. An article on Newscientist describes the basic problem:
…according to calculations by Simon Laughlin of the University of Cambridge and colleagues, axons thinner than 0.1 μm simply shouldn’t work. Axons carry messages in waves of electrical activity called action potentials, which are generated when a chemical signal causes a large number of channels in a cell’s outer membrane to open and allow positively charged ions into the axon. At any given moment some of those channels may open spontaneously, but the number involved isn’t enough to accidentally trigger an action potential, says Laughlin – unless the axon is very thin.
So how do the wasps continue to fly around and parasitize the eggs of other creatures if the electrical impulses of their brains do not work? German researchers speculate that the axons of wasp brains work mechanically rather than electrically. The tiny axons touch each other physically instead of by means of electrical action. If this is correct it means the wasps are analogue creatures with little clockwork minds! If they were any larger or more complex, this would not work, but because of their small size and simple drives, they can manage to operate with slow-moving machine-like brains.