Here is a dramatic and visceral Pieta painted by Carlo Crivelli in 1476 for the church of San Domenico at Ascoli Piceno in the Marches.  The Metropolitan Museum of Art has an interactive web gallery which allows the viewer to magnify this painting in order to see fine details.  Notice how the crown of thorns has sunk its infected barbs into Christ’s head and how intricately Crivelli has rendered the veins of the figures’ hands.